Hepatocyte growth factor/scatter factor is present in most pleural effusion fluids from cancer patients
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منابع مشابه
Serum concentrations of hepatocyte growth factor in breast cancer patients.
Hepatocyte growth factor (HGF) was first identified as a potent stimulator of hepatocyte growth and DNA synthesis. Later, it was shown that HGF can promote cell motility and cell proliferation in various types of cells, including tumor cells and endothelial cells. We have examined serum concentrations of HGF in breast cancer patients using an ELISA. Of 134 primary breast cancer patients, 49 (36...
متن کاملHepatocyte growth factor is a mitogen for Schwann cells and is present in neurofibromas.
To characterize mitogens that might contribute to Schwann cell proliferation during development or in tumors, we tested the ability of hepatocyte growth factor (HGF) to stimulate Schwann cell division in vitro. HGF is a potent mitogen for purified rat Schwann cells; DNA synthesis in rat Schwann cells was stimulated 20-40-fold by 3-10 ng/ml HGF. Rat Schwann cells express c-met mRNA, encoding the...
متن کاملSerum Vascular Endothelial Growth Factor in Pediatric Patients with Community-Acquired Pneumonia and Pleural Effusion
This study investigated the serum vascular endothelial growth factor (VEGF) levels in children with community-acquired pneumonia. Serum VEGF levels were measured in patients with pneumonia (n=29) and in control subjects (n=27) by a sandwich enzyme-linked immunosorbent assay. The pneumonia group was classified into bronchopneumonia with pleural effusion (n=1), bronchopneumonia without pleural ef...
متن کاملHepatocyte growth factor is a prognostic marker in patients with colorectal cancer: a meta-analysis
Hepatocyte growth factor (HGF) is a crucial factor associated with development, progression and metastasis of colorectal cancer (CRC). However, its prognostic value remains unclear. Thus studies referring to the correlation between HGF and CRC patients' prognosis were included to explore the role of HGF in CRC. At last nine articles were included. The results showed that the over-expression of ...
متن کاملHepatocyte growth factor and the hepatocyte growth factor receptor signalling complex as targets in cancer therapies
Since its discovery in the late 1980s 1,2, hepatocyte growth factor (HGF) has been under intense investigation for its role in cancer. Hepatocyte growth factor has been established as a mitogen that regulates cell growth and death, a motogen that stimulates cell motility, a morphogen that modulates cell morphology and tissue or organ regeneration, and an angiogenic factor that induces angiogene...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1996
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1996.64